New Anti-tumor compounds from Curcumin

From the results of research conducted by Chieko Kudo, Hiroyuki Yamakoshi, Atsuko Sato, Hiroshi Nanjo, Hisatsugu Ohori, Chikashi Ishioka, Yoshiharu Iwabuchi and Hiroyuki Shibata titled "Synthesis of 86 species of 1,5-diaryl-3-oxo-1, 4 -pentadienes analogs of curcumin can yield a good lead in vivo "published by BioMed. Stating that they successfully synthesize new anti-tumor compounds.

Curcumin is known to have many anti-tumor such as tumor growth inhibition and induction apotosis. However, the limited bioavailability of curcumin prevented clinical application. A synthesized curcumin analogues, 1,5-diaryl-3-oxo-1 ,4-pentadiene as GO-Y030, has the potential for increased anti-tumor in vitro and in mouse models of colorectal carcinogenesis.

From the results of tests on mice, they found a survival rate of mice given the compounds synthesized. The conclusions of their research are:

The 1,5-diaryl-3-oxo-1 ,4-pentadiene analogs can yield good lead compounds for cancer chemotherapy, to Overcome the low bioavailability of curcumin.

For the full article on this research. You can read it at the following link;
http://www.biomedcentral.com/1471-2210/11/4