From the results of research conducted by Chieko Kudo, Hiroyuki Yamakoshi, Atsuko Sato, Hiroshi Nanjo, Hisatsugu Ohori, Chikashi Ishioka, Yoshiharu Iwabuchi and Hiroyuki Shibata titled "Synthesis of 86 species of 1,5-diaryl-3-oxo-1, 4 -pentadienes analogs of curcumin can yield a good lead in vivo "published by BioMed. Stating that they successfully synthesize new anti-tumor compounds.
Curcumin is known to have many anti-tumor such as tumor growth inhibition and induction apotosis. However, the limited bioavailability of curcumin prevented clinical application. A synthesized curcumin analogues, 1,5-diaryl-3-oxo-1 ,4-pentadiene as GO-Y030, has the potential for increased anti-tumor in vitro and in mouse models of colorectal carcinogenesis.
From the results of tests on mice, they found a survival rate of mice given the compounds synthesized. The conclusions of their research are:
The 1,5-diaryl-3-oxo-1 ,4-pentadiene analogs can yield good lead compounds for cancer chemotherapy, to Overcome the low bioavailability of curcumin.
For the full article on this research. You can read it at the following link;
http://www.biomedcentral.com/1471-2210/11/4
Tampilkan postingan dengan label Article. Tampilkan semua postingan
Tampilkan postingan dengan label Article. Tampilkan semua postingan
The History of Breast Cancer
Fighting the Most Common Cancer in Women
In the 1970's the movement to increase breast cancer awareness began to grow rapidly. More and more non-profit organizations, governmental organizations and other organizations have been formed in order to increase knowledge and awareness of this disease, but also to sponsor research to aid in its eradication. While breast cancer survival rates have gone up somewhat in the last twenty years, the fact remains that this disease is still far too prevalent and killing far too many women.
The history of breast cancer is a long and far too often tragic one. The earliest recorded cases of the disease date back to ancient Egypt. The three earliest documented cases arise from the famous Edwin Smith Papyrus, one of whom was a man. Breast cancer treatment began in the 18th century and is still being researched and developed to this day.
The earliest known medical document known to man is what is known as the Edwin Smith Papyrus. Edwin Smith was an Egyptologist who bought fragments of the document in London in 1862. Although he understood its importance he never published on it and the papyrus became all but forgotten. In the 20th century this vastly important work was rediscovered. Dating back to 1600 BC it is our first known medical writing. Important to the history of breast cancer it also describes in writing the earliest known cases of the disease, one of which was a man.
In ancient Egypt the history of breast cancer treatment begins with cauterization of tumors found in the breast with an instrument known as "the fire drill." Although medical practitioners are able to remove these tumors in some cases they are for the most part unable to stop the disease from taking its course. Writes the ancient Egyptian doctor of breast cancer: "There is no treatment."
Such was the prevailing wisdom throughout the history of breast cancer. Although cases of breast cancer are documented throughout history, it is not until the 17th century in Europe that medical understanding of the human body is able to begin to comprehend the nature of breast cancer. European doctors linked the tumors in the breast to the lymph glands in the armpit. In the early 18th century two extremely important figures in the history of breast cancer arise: Jean Louis Petit and Benjamin Bell who performed the first surgeries removing the lymph nodes, breast tissue and breast muscle in order to remove the cancer from the body and fight its spread.
This pioneering work was continued by the surgeon William Stewart Halsted who began performing complete mastectomies in 1882. His procedure is known as the Halsted radical mastectomy and was popular throughout the 20th century up until the 1970's and is still common today.
Although doctors have been fighting breast cancer for centuries, it was not until the 20th century that movements to increase breast cancer awareness as well as cancer awareness in general began. In 1952 the American Cancer Society created the Reach to Recovery program, one of the landmark programs in the history of breast cancer treatment and advocacy. The Reach to Recovery program was a group of women helping women, where women would go visit patients in hospitals who had just had mastectomies for support. This group continues its operations today.
In the 1970's the movement to increase breast cancer awareness began to grow rapidly. More and more non-profit organizations, governmental organizations and other organizations have been formed in order to increase knowledge and awareness of this disease, but also to sponsor research to aid in its eradication. While breast cancer survival rates have gone up somewhat in the last twenty years, the fact remains that this disease is still far too prevalent and killing far too many women.
Many great strides have been made in the history of breast cancer treatment but there is still a great amount of work to be done. One in 12 or 13 women will suffer from breast cancer at some time during their lives in the western world. In the United States these numbers can be even higher. One of the most important aspects of the fight against breast cancer is breast cancer awareness. The more knowledge known about the disease and the more done to check for early warning signs the better chance for survival. Research and development continues to be done so that one day we can say the history of breast cancer is over.
Review of: Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
Breast Cancer Online (2008), 11:e2 Cambridge University Press
Copyright © Cambridge University Press 2008
doi:10.1017/S1470903108006688
Alex Swarbricka1 c1
a1 Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Abstract
Citation of the original article: L. Ma, J. Teruya-Feldstein, R. A. Weinberg. Nature 2007; 449(7163): 682–688; Epub 26 September 2007.
Abstract of the original article: MicroRNAs have been implicated in regulating diverse cellular pathways. Although there is emerging evidence that some microRNAs can function as oncogenes or tumour suppressors, the role of microRNAs in mediating cancer metastasis remains unexplored. Here we show, using a combination of mouse and human cells, that microRNA-10b (miR-10b) is highly expressed in metastatic breast cancer cells and positively regulates cell migration and invasion. Overexpression of miR-10b in otherwise non-metastatic breast tumours initiates robust invasion and metastasis. Expression of miR-10b is induced by the transcription factor Twist, which binds directly to the putative promoter of miR-10b (MIRN10B). The miR-10b induced by Twist proceeds to inhibit translation of the messenger RNA encoding homeobox D10, resulting in increased expression of a well-characterized pro-metastatic gene, RhoC. Significantly, the level of miR-10b expression in primary breast carcinomas correlates with clinical progression. These findings suggest the workings of an undescribed regulatory pathway, in which a pleiotropic transcription factor induces expression of a specific microRNA, which suppresses its direct target and in turn activates another pro-metastatic gene, leading to tumour cell invasion and metastasis.
Source & Download PDF http://journals.cambridge.org/action/displayFulltext?type=1&fid=1701864&jid=&volumeId=&issueId=01&aid=1701856
Langganan:
Postingan (Atom)
Postingan
